How nicotine ‘works’
Tuesday, March 21st, 2006Someone was asking a while back about how nicotine ‘works’……
Here’s a re-post from the archives on this subject, written by Steve
(post no.61)
Quitting initiates physiological changes. A quick explanation of how
nerve impulses do their ‘thing’… there are tiny gaps between nerve
cells. In order for an impulse to cross that gap, the ’sending’ nerve
cell floods the gap with a neurotransmitter, in this case
acetylcholine. This acts like a chemical ‘bridge’ allowing the nerve
impulse to cross the gap and bind to receptors on the receiving cell.
Immediately afterward, another chemical floods the gap and absorbs
(reuptake) the acetylcholine. This clears the gap so the process can
be repeated again. If that ‘re-absorption’ doesn’t happen or happens
slowly, that gap is effectively ‘frozen’ until it’s cleared. Now
here’s how nicotine works…. it mimics acetylcholine but it’s not
identical. Nicotine is stronger which is why small doses stimulate.
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